Intrahepatic cholestasis; Extrahepatic cholestasis
Cholestasis is any condition in which the flow of bile from the liver is slowed or blocked.
There are many causes of cholestasis.
Extrahepatic cholestasis occurs outside the liver. It can be caused by:
Intrahepatic cholestasis occurs inside the liver. It can be caused by:
Certain medicines can also cause cholestasis, including:
Symptoms may include:
Imaging tests are used to diagnose this condition. Tests include:
The underlying cause of cholestasis must be treated.
How well a person does depends on the disease causing the condition. Stones in the common bile duct can often be removed. This can cure the cholestasis.
Stents can be placed to open areas of the common bile duct that are narrowed or blocked by cancers.
If the condition is caused by the use of a certain medicine, it will often go away when you stop taking that drug.
Complications may include:
Call your health care provider if you have:
Get vaccinated for hepatitis A and B if you are at risk. Do not use intravenous drugs and share needles.
Eaton JE, Lindor KD. Primary biliary chirrhosis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 91.
Fogel EL, Sherman S. Diseases of the gallbladder and liver. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 155.
Lidofsky SD. Jaundice. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 21.BACK TO TOP
Review Date: 4/18/2018
Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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