Sustained virologic response - hepatitis C; SVR - hepatitis C
Hepatitis C is a viral disease that leads to swelling (inflammation) of the liver.
Other types of viral hepatitis include:
Hepatitis C infection is caused by the hepatitis C virus (HCV).
You can catch hepatitis C if the blood of someone who has hepatitis C enters your body. Exposure may occur:
People at risk of hepatitis C are those who:
Most people who are recently infected with hepatitis C do not have symptoms. Some people have yellowing of the skin (jaundice). Chronic infection often causes no symptoms. But fatigue, depression and other problems can occur.
Persons who have long-term (chronic) infection often have no symptoms until their liver becomes scarred (cirrhosis). Most people with this condition are ill and have many health problems.
The following symptoms may occur with hepatitis C infection:
Blood tests are done to check for hepatitis C:
Everyone born from 1945 to 1965 (the baby boomer generation) should get a one-time test for hepatitis C.
Genetic testing is done to check for the type of hepatitis C (genotype). There are six types of the virus (genotypes 1 through 6). Test results can help your doctor choose treatment that is best for you.
The following tests are done to identify and monitor liver damage from hepatitis C:
You should talk to your health care provider about your treatment options and when treatment should begin.
Antiviral medicines are used to treat hepatitis C. These drugs help fight the HCV. Newer antiviral drugs:
The choice of which medicine depends on the genotype of the HCV you have.
A liver transplant may be recommended for people who develop cirrhosis and/or liver cancer. Your provider can tell you more about liver transplant.
If you have hepatitis C:
Joining a support group can help ease the stress of having hepatitis C. Ask your provider about liver disease resources and support groups in your area.
Most people (75% to 85%) who are infected with the virus develop chronic hepatitis C. This condition poses a risk for cirrhosis, liver cancer, or both. The outlook for hepatitis C depends in part on the genotype.
A good response to treatment occurs when the virus can no longer be detected in the blood 12 weeks or more after treatment. This is called "sustained virologic response" (SVR). Up to 90% of those treated for some genotypes have this type of response.
Some people do not respond to initial treatment. They may need to be re-treated with a different class of medicines.
Also, some people can become re-infected or infected with a different genotype strain.
Call your provider if:
Steps that can be taken to help prevent the spread of hepatitis C from one person to another include:
If you or your partner is infected with hepatitis C and you have been in a stable and monogamous (no other partners) relationship, the risk of giving the virus to, or getting the virus from, the other person is low.
HCV cannot be spread by casual contact, such as holding hands, kissing, coughing or sneezing, breastfeeding, sharing eating utensils or drinking glasses.
Currently there is no vaccine for hepatitis C.
Centers for Disease Control and Prevention website. Hepatitis C. www.cdc.gov/hepatitis/hcv/cfaq.htm. Updated October 17, 2016. Accessed March 11, 2018.
Fathi H, Clark A, Hill NR, Dusheiko G. Effectiveness of current and future regimens for treating genotype 3 hepatitis C virus infection: a large-scale systematic review. BMC Infect Dis. 2017;17(1):722 PMID: 29145802 www.ncbi.nlm.nih.gov/pubmed/29145802.
Falade-Nwulia O, Suarez-Cuervo C, Nelson DR, Fried MW, Segal JB, Sulkowski MS. Oral direct-acting agent therapy for hepatitis C virus infection: a systematic review. Ann Intern Med. 2017;166(9):637-648. PMID: 28319996 www.ncbi.nlm.nih.gov/pubmed/28319996.
Ferreira VL, Assis Jarek NA, Tonin FS, et al. Ledipasvir/sofosbuvir with or without ribavirin for the treatment of chronic hepatitis C genotype 1: A pairwise meta-analysis. J Gastroenterol Hepatol. 2017;32(4):749-755. PMID: 27785825 www.ncbi.nlm.nih.gov/pubmed/27785825.
Jakobsen JC, Nielsen EE, Feinberg J, et al. Direct-acting antivirals for chronic hepatitis C. Cochrane Database Syst Rev. 2017;9:CD012143. PMID: 28585310www.ncbi.nlm.nih.gov/pubmed/28922704.
Jacobson IM, Lim JK, Fried MW. American Gastroenterological Association Institute clinical practice update-expert review: care of patients who have achieved a sustained virologic response after antiviral therapy for chronic hepatitis C infection. Gastroenterology. 2017;152(6):1578-1587 PMID: 28344022. www.ncbi.nlm.nih.gov/pubmed/28344022.
Moyer VA; U.S. Preventive Services Task Force. Screening for hepatitis C virus infection in adults. U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;159(5):349-357. PMID: 23798026 www.ncbi.nlm.nih.gov/pubmed/23798026.
Ray SC, Thomas DL. Hepatitis C. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 156.
Wedemeyer H. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 80.BACK TO TOP
Review Date: 1/12/2018
Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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