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Hemolytic anemia

Anemia - hemolytic

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.

Normally, red blood cells last for about 120 days in the body. In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal.

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Red blood cells, sickle cell
Red blood cells - multiple sickle cells
Red blood cells - sickle cells
Red blood cells - sickle and Pappenheimer
Blood cells

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Causes

The bone marrow is mostly responsible for making new red cells. Bone marrow is the soft tissue in the center of bones that helps form all blood cells.

Hemolytic anemia occurs when the bone marrow isn't making enough red cells to replace the ones that are being destroyed.

There are several possible causes of hemolytic anemia. Red blood cells may be destroyed due to:

Symptoms

You may not have symptoms if the anemia is mild. If the problem develops slowly, the first symptoms may be:

If the anemia gets worse, symptoms may include:

Exams and Tests

A test called a complete blood count (CBC) can help diagnose anemia and offer some hints to the type and cause of the problem. Important parts of the CBC include red blood cell count (RBC), hemoglobin, and hematocrit (HCT).

These tests can identify the type of hemolytic anemia:

Treatment

Treatment depends on the type and cause of the hemolytic anemia:

In rare cases, surgery is needed to take out the spleen. This is because the spleen acts as a filter that removes abnormal cells from the blood.

Outlook (Prognosis)

Outcome depends on the type and cause of hemolytic anemia. Severe anemia can make heart disease, lung disease, or cerebrovascular disease worse.

When to Contact a Medical Professional

Call your health care provider if you develop symptoms of hemolytic anemia.

Related Information

Anemia
Intrinsic factor
Autoimmune disorders
Sickle cell disease
Glucose-6-phosphate dehydrogenase deficiency
Hereditary spherocytic anemia
Immune hemolytic anemia
Cardiovascular
Stroke

References

Brodsky RA. Paroxysmal nocturnal hemoglobinuria. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 31.

Gallagher PG. Hemolytic anemias: Red blood cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 161.

Kumar V, Abbas AK, Aster JC. Hematopoietic and lymphoid systems. In: Kumar V, Abbas AK, Aster JC, eds. Robbins Basic Pathology. 10th ed. Philadelphia, PA: Elsevier; 2018:chap 12.

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Review Date: 1/19/2018  

Reviewed By: Richard LoCicero, MD, private practice specializing in hematology and medical oncology, Longstreet Cancer Center, Gainesville, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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