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Immune hemolytic anemia

Anemia - immune hemolytic; Autoimmune hemolytic anemia (AIHA)

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to the body's tissues.

Red blood cells last for about 120 days before the body gets rid of them. In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal.

Immune hemolytic anemia occurs when antibodies form against the body's own red blood cells and destroy them. This happens because the immune system mistakenly recognizes these blood cells as foreign.

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Antibodies

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Causes

Possible causes include:

When antibodies form against red blood cells for no reason, the condition is called idiopathic autoimmune hemolytic anemia.

The antibodies may also be caused by:

Risk factors are related to the causes.

Symptoms

You may not have symptoms if the anemia is mild. If the problem develops slowly, symptoms that may occur first include:

If the anemia gets worse, symptoms may include:

Exams and Tests

You may need the following tests:

Treatment

The first treatment tried is most often a steroid medicine, such as prednisone. If steroid medicine do not improve the condition, treatment with intravenous immunoglobulin (IVIG) or removal of the spleen (splenectomy) may be considered.

You may receive treatment to suppress your immune system if you do not respond to steroids. Drugs such as azathioprine (Imuran), cyclophosphamide (Cytoxan), and rituximab (Rituxan) have been used.

Blood transfusions are given with caution, because the blood may not be compatible and it may cause more red blood cell destruction.

Outlook (Prognosis)

The disease may start quickly and be very serious, or it may stay mild and not need special treatment.

In most people, steroids or splenectomy can totally or partially control anemia.

Possible Complications

Severe anemia rarely leads to death. Severe infection may occur as a complication of treatment with steroids, other medicines that suppress the immune system, or splenectomy. These treatments impair the body's ability to fight infection.

When to Contact a Medical Professional

Call your health care provider if you have unexplained fatigue or chest pain, or signs of infection.

Prevention

Screening for antibodies in donated blood and in the recipient may prevent hemolytic anemia related to blood transfusions.

Related Information

Antibody
Hemolytic anemia

References

Michel M. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 160.

Michel M, Jäger U. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 46.

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Review Date: 1/19/2018  

Reviewed By: Richard LoCicero, MD, private practice specializing in hematology and medical oncology, Longstreet Cancer Center, Gainesville, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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