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Hypothalamic dysfunction

Hypothalamic syndromes

Hypothalamic dysfunction is a problem with part of the brain called the hypothalamus. The hypothalamus helps control the pituitary gland and regulates many body functions.

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Central nervous system and peripheral nervous system
Hypothalamus

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Causes

The hypothalamus helps keep the body's internal functions in balance. It helps regulate:

Another important function of the hypothalamus is to control the pituitary gland. The pituitary is a small gland at the base of the brain. It lies just below the hypothalamus. The pituitary, in turn, controls the:

There are many causes of hypothalamic dysfunction. The most are surgery, traumatic brain injury, tumors, and radiation.

Other causes include:

Symptoms

Symptoms are usually due to the hormones or brain signals that are missing. In children, there may be growth problems, either too much or too little growth. In other children, puberty occurs too early or too late.

Tumor symptoms may include headache or loss of vision.

Hypothyroidism symptoms may include feeling cold all the time, constipation, fatigue, or weight gain, among others.

Low adrenal function symptoms may include fatigue, weakness, poor appetite, weight loss, and lack of interest in activities.

Exams and Tests

The health care provider will perform a physical examination and ask about your symptoms.

Blood or urine tests may be ordered to determine levels of hormones such as:

Other possible tests include:

Treatment

Treatment depends on the cause of the hypothalamic dysfunction:

Outlook (Prognosis)

Many causes of hypothalamic dysfunction are treatable. Most of the time, missing hormones can be replaced.

Possible Complications

Complications of hypothalamic dysfunction depend on the cause.

BRAIN TUMORS

HYPOTHYROIDISM

ADRENAL INSUFFICIENCY

SEX GLAND DEFICIENCY

GROWTH HORMONE DEFICIENCY

When to Contact a Medical Professional

Call your provider if you have:

Prevention

If you have symptoms of a hormonal deficiency, discuss replacement therapy with your provider.

Related Information

Hypothalamus
Anorexia
Bulimia

References

Giustina A, Braunstein GD. Hypothalamic syndromes. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 10.

Molitch ME. Neuroendocrinology and the neuroendocrine system. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 223.

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Review Date: 5/7/2017  

Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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