Serum creatinine clearance; Kidney function - creatinine clearance; Renal function - creatinine clearance
The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the creatinine level in urine with the creatinine level in blood.
Your health care provider may ask you to temporarily stop any medicines that may affect the test results. These include some antibiotics and stomach acid medicines. Be sure to tell your provider about all the medicines you take.
DO NOT stop taking any medicine before talking to your provider.
The urine test involves only normal urination. There is no discomfort.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Creatinine is a chemical waste product of creatine. Creatine is a chemical the body makes to supply energy, mainly to muscles.
By comparing the creatinine level in urine with the creatinine level in blood, this test estimates the glomerular filtration rate (GFR). GFR is a measure of how well the kidneys are working, especially the kidneys' filtering units. These filtering units are called glomeruli.
Creatinine is removed, or cleared, from the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood because less creatinine is released through the urine.
Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are:
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor to know about the meaning of your specific test results.
Abnormal results (lower than normal creatinine clearance) may indicate:
Risks of the test involve the blood draw process.
Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
Chernecky CC, Berger BJ. Creatinine clearance - serum and urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:401-403.
Inker LA, Fan L, Levey AS. Assessment of renal function. In: Johnson RJ, Feehally J, Floege J, eds. Comprehensive Clinical Nephrology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 3.
Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 114.BACK TO TOP
Review Date: 7/15/2017
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2019 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.