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Fluorescein angiography

Retinal photography; Eye angiography; Angiography - fluorescein

Fluorescein angiography is an eye test that uses a special dye and camera to look at blood flow in the retina and choroid. These are the two layers in the back of the eye.

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Retinal dye injection

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How the Test is Performed

You will be given eye drops that make your pupil dilate. You will be asked to place your chin on a chin rest and your forehead against a support bar to keep your head still during the test.

The health care provider will take pictures of the inside of your eye. After the first group of pictures is taken, a dye called fluorescein is injected into a vein. Most often it is injected at the inside of your elbow. A camera-like device takes pictures as the dye moves through the blood vessels in the back of your eye.

A newer method called ultra-widefield fluorescein angiography can provide more information about certain diseases than regular angiography.

How to Prepare for the Test

You will need someone to drive you home. Your vision may be blurry for up to 12 hours after the test.

You may be told to stop taking medicines that could affect the test results. Tell your provider about any allergies, particularly reactions to iodine.

You must sign an informed consent form. You must remove contact lenses before the test.

Tell the provider if you may be pregnant.

How the Test will Feel

When the needle is inserted, some people feel slight pain. Others feel only a prick or sting. Afterward, there may be some throbbing.

When the dye is injected, you may have mild nausea and a warm feeling in your body. These symptoms go away quickly most of the time.

The dye will cause your urine to be darker. It may be orange in color for a day or two after the test.

Why the Test is Performed

This test is done to see if there is proper blood flow in the blood vessels in the two layers in the back of your eye (the retina and choroid).

It can also be used to diagnose problems in the eye or to determine how well certain eye treatments are working.

Normal Results

A normal result means the vessels appear a normal size, there are no new abnormal vessels, and there are no blockages or leakages.

What Abnormal Results Mean

If blockage or leakage is present, the pictures will map the location for possible treatment.

An abnormal value on a fluorescein angiography may be due to:

The test may also be done if you have:

Risks

There is a slight chance of infection any time the skin is broken. Rarely, a person is overly sensitive to the dye and may experience:

Serious allergic reactions are rare.

Considerations

The test results are harder to interpret in people with cataracts.

Related Information

Retina
Retinopathy of prematurity
Diabetes and eye disease
High blood pressure and eye disease
Macular degeneration - age-related
Retinal detachment
Retinal artery occlusion
Retinitis pigmentosa

References

Feinstein E, Olson JL, Mandava N. Camera-based ancillary retinal testing: autofluorescence, fluorescein, and indocyanine green angiography. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 6.6.

Haug S, Fu AD, Johnson RN, McDonald HR, et al. Fluorescein angiography: basic principles and interpretation. In: Schachat AP, Sadda SVR, Hinton DR, Wilkinson CP, Wiedemann P, eds. Ryan's Retina. 6th ed. Philadelphia, PA: Elsevier; 2018:chap 1.

Karampelas M, Sim DA, Chu C, et al. Quantitative analysis of peripheral vasculitis, ischemia, and vascular leakage in uveitis using ultra-widefield fluorescein angiography. Am J Ophthalmol. 2015;159(6):1161-1168. PMID: 25709064 www.ncbi.nlm.nih.gov/pubmed/25709064.

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Review Date: 8/28/2018  

Reviewed By: Franklin W. Lusby, MD, ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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