Hypothalamic tumorHypothalamic glioma; Hypothalamus - tumor
A tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).
The hypothalamus is an area of the brain that produces hormones that control:Body temperatureHungerMoodRelease of hormones from many glands, especial...
The exact cause of hypothalamic tumors is not known. It is likely that they result from a combination of genetic and environmental factors.
In children, most hypothalamic tumors are gliomas. Gliomas are a common type of brain tumor that results from the abnormal growth of glial cells, which support nerve cells. Gliomas can occur at any age. They are often more aggressive in adults than in children.
In adults, tumors in the hypothalamus are more likely cancer that has spread from another organ.
People with neurofibromatosis (a hereditary condition) are at increased risk for this type of tumor. People who have undergone radiation therapy are at increased risk of developing tumors in general.
Neurofibromatosis-1 (NF1) is an inherited disorder in which nerve tissue tumors (neurofibromas) form in the: Bottom layer of skin (subcutaneous tissu...
These tumors can cause a range of symptoms:
- Euphoric "high" sensations
- Failure to thrive (lack of normal growth in children)
- Loss of body fat and appetite (cachexia)
These symptoms are most often seen in children whose tumors affect the front part of the hypothalamus.
Some tumors may cause vision loss. If the tumors block the flow of spinal fluid, headaches and sleepiness may result from fluid collecting in the brain (hydrocephalus).
Hydrocephalus is a buildup of fluid inside the skull that leads to brain swelling. Hydrocephalus means "water on the brain. "
Some people can have seizures as a result of brain tumors. Other people may develop precocious puberty from a change in pituitary gland function.
Puberty is the time during which a person's sexual and physical characteristics mature. Precocious puberty is when these body changes happen earlier...
Exams and Tests
Your health care provider may see signs of a hypothalamic tumor during a regular checkup. A brain and nervous system (neurological) exam, including tests of visual function, may be done. Blood tests for hormone imbalances may also be ordered.
The visual acuity test is used to determine the smallest letters you can read on a standardized chart (Snellen chart) or a card held 20 feet (6 meter...
A computed tomography (CT) scan is an imaging method that uses x-rays to create pictures of cross-sections of the body. Related tests include:Abdomin...
A magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...
Visual field testing may be done to check for vision loss, and to determine whether the condition is improving or getting worse.
Visual field testing
The visual field refers to the total area in which objects can be seen in the side (peripheral) vision as you focus your eyes on a central point. Thi...
Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells.
The term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...
Special radiation treatments can be focused on the tumor. They can be as effective as surgery, with less risk to surrounding tissue. Brain swelling caused by a tumor may need to be treated with steroids.
Hypothalamic tumors may produce hormones or affect hormone production, leading to imbalances that may need to be corrected. In some cases, hormones may need to be replaced or reduced.
You can often help the stress of illness by joining a support group where members share common experiences and problems.
The following organizations are good resources for information on cancer:American Cancer Society -- www. cancer. orgAmerican Childhood Cancer Organiz...
The outlook depends on:
- The type of tumor (glioma or other type)
- Location of tumor
- Grade of tumor
- Size of tumor
- Your age and general health
In general, gliomas in adults are more aggressive than in children and usually have a worse outcome. Tumors that cause hydrocephalus may cause more complications, and may need surgery.
Complications of brain surgery may include:
- Brain damage
- Death (rarely)
Seizures can result from the tumor or from any surgical procedure on the brain.
Hydrocephalus can occur with some tumors and can require surgery or a catheter placed in the brain to reduce spinal fluid pressure.
Risks for radiation therapy include damage to healthy brain cells when tumor cells are destroyed.
Common side effects from chemotherapy include loss of appetite, nausea and vomiting, and fatigue.
When to Contact a Medical Professional
Call your provider if you or your child develops any symptoms of a hypothalamic tumor. Regular medical check-ups may detect early signs of a problem, such as abnormal weight gain or early puberty.
Molitch ME. Neuroendocrinology and the neuroendocrine system. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 223.
Ntali G, Karavitaki N. Childhood hypothalamic and pituitary tumors. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 17.
Review Date: 1/19/2018
Reviewed By: Richard LoCicero, MD, private practice specializing in hematology and medical oncology, Longstreet Cancer Center, Gainesville, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.