Adult soft tissue sarcomaSTS; Leiomyosarcoma; Hemangiosarcoma; Kaposi's sarcoma; Lymphangiosarcoma; Synovial sarcoma; Neurofibrosarcoma; Liposarcoma; Fibrosarcoma; Malignant fibrous histiocytoma; Dermatofibrosarcoma; Angiosarcoma
Soft tissue sarcoma (STS) is cancer that forms in the soft tissue of the body. Soft tissue connects, supports, or surrounds other body parts. In adults, STS is rare.
There are many different types of soft tissue cancers. The type of sarcoma depends on the tissue it forms in:
- Blood vessels
- Lymph vessels
- Tissues in and around joints
The cancer can form almost anywhere, but is most common in the:
It is not known what causes most sarcomas. But there are certain risk factors:
- Some inherited diseases, such as Li-Fraumeni syndrome
- Radiation therapy for other cancers
- Exposure to certain chemicals, such as vinyl chloride or certain herbicides
- Having swelling in the arms or legs for a long time (lymphedema)
In early stages, there are often no symptoms. As the cancer grows, it may cause a lump or swelling that keeps growing over time. Most lumps are NOT cancer.
Other symptoms include:
- Pain, if it presses on a nerve, organ, blood vessel, or muscle
- Blockage or bleeding in the stomach or intestines
- Breathing problems
Exams and Tests
Your health care provider will ask you about your medical history and do a physical exam. Other tests may include:
If your provider suspects cancer, you might have a biopsy to check for cancer. In a biopsy, your provider collects a tissue sample to examine in the lab.
A biopsy is the removal of a small piece of tissue for laboratory examination.
The biopsy will show if cancer is present and help show how quickly it is growing. Your provider may ask for more tests to stage the cancer. Staging can tell how much cancer is present and whether it has spread.
Stage the cancer
Cancer staging is a way to describe how much cancer is in your body and where it is located in your body. Staging helps determine where the original...
Surgery is the most common treatment for STS.
- In early stages, the tumor and some healthy tissue around it is removed.
- Sometimes, just a small amount of tissue needs to be removed. Other times, a wider area of tissue must be removed.
- With advanced cancers that form in an arm or leg, surgery may be followed by radiation or chemotherapy. Rarely, the limb may need to be amputated.
Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells.
The term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...
- Used before surgery to help shrink the tumor to make it easier to remove the cancer
- Used after surgery to kill any remaining cancer cells
Chemotherapy may be used to help kill cancer that has metastasized. This means it has spread to different areas of the body.
Metastasis is the movement or spreading of cancer cells from one organ or tissue to another. Cancer cells usually spread through the blood or the ly...
Cancer affects how you feel about yourself and your life. You can ease the stress of illness by joining a cancer support group. Sharing with others who have had the same experiences and problems can help you feel less alone.
Cancer support group
The following organizations are good resources for information on cancer:American Cancer Society -- www. cancer. orgAmerican Childhood Cancer Organiz...
Ask your provider to help you find a support group for people who have been diagnosed with STS.
The outlook for people whose cancer is treated early is very good. Most people who survive 5 years can expect to be cancer-free at 10 years.
Complications include side effects from surgery, chemotherapy, or radiation.
When to Contact a Medical Professional
See your provider about any lump that grows in size or is painful.
The cause of most STSs isn't known and there is no way to prevent it. Knowing your risk factors and telling your provider when you first notice symptoms can increase your chance of surviving this type of cancer.
Contreras CM, Heslin MJ. Soft tissue sarcoma. In: Townsend CM Jr, Beauchamp RD, Evers BM, Mattox KL, eds. Sabiston Textbook of Surgery. 20th ed. Philadelphia, PA: Elsevier; 2017:chap 31.
Helman LJ, Maki RG. Sarcomas of soft tissue. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 93.
National Cancer Institute website. Adult soft tissue sarcoma treatment (PDQ) - health professional version. www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq#section/all. Updated June 29, 2018. Accessed August 22, 2018.
Review Date: 7/26/2018
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.