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Acute flaccid myelitis

Acute flaccid myelitis; AFM; Polio-like syndrome; Acute flaccid paralysis; Acute flaccid paralysis with anterior myelitis; Anterior myelitis; Enterovirus D68; Enterovirus A71

 

Acute flaccid myelitis is a rare condition that affects the nervous system. Inflammation of the gray matter in the spinal cord leads to muscle weakness and paralysis.

Acute flaccid myelitis (AFM) is usually caused by infection with a virus. While AFM is rare, there has been a slight increase in cases of AFM since 2014. Most new cases have occurred in children or young adults.

Causes

 

AFM usually occurs after a cold, fever, or gastrointestinal illness.

Different kinds of viruses may be the cause of AFM. These include:

  • Enteroviruses (poliovirus and non-poliovirus)
  • West Nile virus and similar viruses such as Japanese encephalitis virus and Saint Louis encephalitis virus
  • Adenoviruses

It is unclear why certain viruses trigger AFM, or why some people develop the condition and others don't.

Environmental toxins also can cause AFM. In many cases, a cause is never found.

 

Symptoms

 

A fever or a respiratory illness is often present before weakness and other symptoms begin.

AFM symptoms often start with sudden muscle weakness and loss of reflexes in an arm or leg. Symptoms may progress rapidly over a few hours to days. Other symptoms may include:

  • Facial droop or weakness
  • Drooping eyelids
  • Difficulty moving the eyes
  • Slurred speech or difficulty swallowing

Some people may have:

  • Stiffness in the neck
  • Pain in the arms or legs
  • Inability to pass urine

Severe symptoms include:

  • Respiratory failure, when muscles involved in breathing become weak
  • Serious nervous system problems, which may lead to death

 

Exams and Tests

 

Your health care provider will take your medical history and vaccination history to know if you are up-to-date with your polio vaccines. Unvaccinated individuals who are exposed to poliovirus are at higher risk for acute flaccid myelitis. Your provider also may want to know if within the last 4 weeks you have:

  • Traveled
  • Had a cold or the flu or a stomach bug
  • Had a fever 100°F (38°C) or higher

Your provider will do a physical exam. Tests that may be done include:

  • MRI of spine and MRI of the brain to view lesions in the gray matter
  • Nerve conduction velocity test
  • Electromyography (EMG)
  • Cerebrospinal fluid (CSF) analysis to check if white blood cells are elevated

Your provider also may take stool, blood, and saliva samples to test.

 

Treatment

 

There is no specific treatment for AFM. You may be referred to a doctor specializing in disorders of the nerves and nervous system (neurologist). The doctor will likely treat your symptoms.

A number of medicines and treatments that work on the immune system have been tried but have not been found to help.

You may need physical therapy to help restore muscle function.

 

Outlook (Prognosis)

 

The long-term outlook of AFM is not known.

 

Possible Complications

 

Complications of AFM include:

  • Muscle weakness and paralysis
  • Loss of limb function

 

When to Contact a Medical Professional

 

Contact your provider right away if you or your child have:

  • Sudden weakness in the arms or legs or difficulty moving the head or face
  • Any other symptom of AFM

 

Prevention

 

There is no clear way to prevent AFM. Having a polio vaccine may help reduce the risk of AFM related to the poliovirus.

Take these steps to help avoid viral infection:

  • Wash hands frequently with soap and water, especially before eating.
  • Avoid close contact with people who have a viral infection.
  • Use mosquito repellants when going outdoors to prevent mosquito bites.

To learn more and get recent updates, go to the CDC webpage about acute flaccid myelitis at www.cdc.gov/acute-flaccid-myelitis/index.html.

 

 

References

Centers for Disease Control and Prevention website. Acute flaccid myelitis. www.cdc.gov/acute-flaccid-myelitis/index.html. Updated October 22, 2018. Accessed October 30, 2018.

Genetic and Rare Diseases Information Center website. Acute flaccid myelitis. US Department of Health and Human Services. National Institute of Health. rarediseases.info.nih.gov/diseases/13142/acute-flaccid-myelitis. Updated October 9, 2018. Accessed October 30, 2018

Messacar K, Modlin JF, Abzug MJ. Enteroviruses and parechoviruses. In: Long SS, Prober CG, Fischer M eds. Principles and Practice of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 236.

Messacar K, Schreiner TL, Van Haren K, et al. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016;80(3):326-338. PMID: 27422805 www.ncbi.nlm.nih.gov/pubmed/27422805.

Strober JB, Glaser CA. Parainfectious and postinfectious neurologic syndromes. In: Long SS, Prober CG, Fischer M eds. Principles and Practice of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 45.

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            Review Date: 11/2/2018

            Reviewed By: Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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